Our basic science laboratories are based on Level 6 of the Addenbrooke’s Centre for Clinical Investigation (ACCI). We have a number of PIs whose interests lie primarily within the domain of translational research. A short summary is provided but please see individual investigator’s pages for further information. We give equal weight to the clinical and non-clinical members of the Unit, encouraging the clinicians to learn basic science skills, and the scientists to take part in patient-orientated research.

Many of our research outputs have been translated rapidly into improving practices, mainly in hypertension, where both diagnosis and treatment has been transformed by our AB/CD rule, which forms the basis of the NICE/BHS joint guidelines for the management of hypertension and use of plasma renin as a routine test in most patients.

Details

Dr Anthony Davenport : Role of G-protein coupled rceptors in the cardiovascular system to identify new targets for novel drugs

Dr Thomas Krieg : Identifying molecular mechanisms underlying ischaemic myocardial cell death to inform new therapies

Dr Janet Maguire : Pharmacology of G-protein coupled receptors

Dr Kevin O’Shaughnessy : Molecular genetics of essential hypertension and pre-eclampsia as well as mechanisms of salt handling in the renal tubule to inform more targeted therapies for hypertension

Dr Yasmin : Molecular genetics of hypertension and arterial stiffness.