Affiliated Associate Professor, Department of Medicine, University of Cambridge

Consultant Physician and Clinical Pharmacologist, Cambridge University Hospitals NHS Foundation Trust

Director of the Cardiovascular Clinical Trials Office, Cambridge University Hospitals NHS Foundation Trust

Training Programme Director, Clinical Pharmacology & Therapeutics, Health Education England, East of England

Advisor, Scientific Review Panel for Phase 1 studies, Clinical Research Malaysia and Malaysian Ministry of Health

Email:  jc403@cam.ac.uk

Tel: 01223 256653

Websites:

LinkedIn

Cambridge Medical Seminars

Experimental Medicine Training Initiative

Research and Academic Interests

My research focuses on vascular function and inflammation, NO bioavailability and vascular-ventricular interactions. I have a keen interest in identifying novel agents that may improve vascular health, as measured in vivo, in human models of health and disease. I was the first MHRA accredited Phase 1 first-in-human physician on the Cambridge Biomedical Campus working in the University/NHS domains since 2006 and we have subsequently expanded this group to 3 qualified physicians. We have conducted early phase trials and experimental medicine studies to dissect mechanisms and pathophysiology in cardiovascular and respiratory medicine since 2006, working closely with industry.

 

 

 

 

Vascular function and inflammation

We use well-described models to characterise this in our Department as well as more experimental approaches to stratify patients. These include forearm plethysmography, flow mediated dilatation and arterial stiffness as well as a range of haemodynamic and circulatory measurements. These biomarkers enable us to understand the mechanisms underlying the improvement or deterioration in vascular health in vivo from an NO bioavailability viewpoint, provide proof of concept of human physiology and pathophysiology and also help interrogate the role of various peptides and hormones in the regulation of vascular tone. The strength of these unique types of clinical physiological studies lies in their direct relevance to human biology, occasionally confirming pre-clinical models, but simultaneously providing relevance to human pathophysiology.

We are also interested in developing more novel approaches to understanding vascular pathophysiology using non-invasive imaging and bespoke technologies to understand angiogenesis. These techniques may be applied to human physiological studies and clinical trials of investigational medicinal products. This enables the translation of pre-clinical models of novel therapeutic agents into niche products differentiating an investigational medicinal product from existing therapies, or providing proof of mechanism in order to progress such a product through the stages of clinical drug development.

For example, building on some seminal work performed by local collaborators, we have used FDG PET-CT in a novel experimental medicine study to understand the effects of a new therapeutic agent in altering the biology of atherosclerosis. We have applied similar techniques to assess existing therapies for patients with chronic inflammatory conditions, to understand if they possess off-target pharmacology which may improve outcomes as an inadvertent benefit of therapy. Along similar lines, we are aiming to understand how new drugs may disrupt vascular networks in the microcirculatory environment by examining the effects of such therapies on conjunctival vessels.

Phase 1/2 and First in human clinical trials in cardiovascular and respiratory disease

We have an active programme of work in early phase studies in the cardiovascular and respiratory arena. This includes repurposing of currently licensed drugs for novel indications where they are currently contraindicated, and until recently in the execution of first in human trials in conjunction with the GSK Clinical Unit based on the campus. Further experimental medicine links are being developed with AstraZeneca whose global headquarters are now in Cambridge.

Most early phase studies now embed proof of mechanism and proof of concept pharmacodynamic markers in their trials to discharge risks and provide evidence of benefit.

We also work closely with other industrial partners on pre-competitive and early phase conceptual studies to provide evidence of target engagement.

Research Echocardiography service

I setup a novel research echocardiography service to help the campus undertake high quality echocardiograms for clinical research studies and trials. This includes academic research studies within the department as well as commercial clinical trials. The lab achieved the European Association of Cardiovascular Imaging accreditation as a mark of the high quality standards employed.

 

Cardiovascular Trials Office & Research Ethics/Governance

I direct the Cardiovascular Trials Office of the Cambridge Clinical Trials Unit which leads the design, implementation and delivery of clinical trials on campus. This includes experimental studies in the cardio-respiratory arena in keeping with the Biomedical Research Centre theme.

I previously served in a voluntary position as Vice Chair of the Health Research Authority Cambridge Research Ethics Committee for >10 years

Teaching

I lead an active programme of educational programmes for junior doctors and medical students. This includes the Cambridge Medical Seminars and the Experimental Medicine Training Initiative for doctoral clinical/non-clinical students. The former was expanded in collaboration with the Royal College of Physicians and the Sunway Group to >5,000 participants in Malaysia and internationally as online webinars during the global COVID-19 pandemic – a huge success for the Sunway-Cambridge collaboration.

Recent Publications

Orcid ID

Pubmed Bibliography

Scopus Author

Google Scholar

2022

• Sriranjan R, Zhao TX, Tarkin J, Hubsch A, Helmy J, Vamvaka E, Jalaludeen N, Bond S, Hoole SP, Knott P, Buckenham S, Warnes V, Bird N, Cheow H, Templin H, Cacciottolo P, Rudd JHF, Mallat Z, Cheriyan J. Low dose interluekin 2 for the reduction of vascular inflation in acute coronary syndromes (IVORY): protocol and study rationale fora randomised, double-blind, placebo-controlled, phase II clinical trial. BMJ Open 2022 Oct 7;12(10):e062602. doi: 10.1136/bmjopen-2022-062602.
• Singh S, Weiss A, Goodman J, Fisk M, Kulkarni S, Lu I, Gray J, Smith R, Sommer M, Cheriyan J.
  Niclosamide-A promising treatment for COVID-19. Br J Pharmacol. 2022 Mar 29. doi: 10.1111/bph.15843.
• Cheriyan J, Roberts A, Roberts C, Graves MJ, Patterson I, Slough RA, Schroyer R, Fernando D, Kumar S, Lee S, Parker GJM, Sarov-Blat L, McEniery C, Middlemiss J, Sprecher D, Janiczek RL.
  Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study. J Magn Reson Imaging. 2022 Mar 27. doi: 10.1002/jmri.28174.
• Abraham GR, Kuc RE, Althage M, Greasley PJ, Ambery P, Maguire JJ, Wilkinson IB, Hoole SP, Cheriyan J, Davenport AP.Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19. J Mol Cell Cardiol. 2022 Mar 23;167:92-96. doi: 10.1016/j.yjmcc.2022.03.007.
• Wechalekar A, Antoni G, Al Azzam W, Bergström M, Biswas S, Chen C, Cheriyan J, Cleveland M, Cookson L, Galette P, Janiczek RL, Kwong RY, Lukas MA, Millns H, Richards D, Schneider I, Solomon SD, Sörensen J, Storey J, Thompson D, van Dongen G, Vugts DJ, Wall A, Wikström G, Falk RH. Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study BMC Cardiovasc Disord. 2022 Feb 13;22(1):49.

2021

• Tian X. Zhao, Rouchelle S. Sriranjan, Zewen Kelvin Tuong, Yuning Lu, Andrew P. Sage, Meritxell Nus, Annette Hubsch, Fotini Kaloyirou, Evangelia Vamvaka, Joanna Helmy, Michalis Kostapanos, Navazh Jalaludeen, David Klatzmann, Alain Tedgui, James H.F. Rudd, Sarah J. Horton, Brian J.P. Huntly, Stephen P. Hoole, Simon P. Bond, Menna R. Clatworthy*, Joseph Cheriyan*, Ziad Mallat* (* joint senior authors) Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease NEJM Evid 2021; 1 (1)
• Yu X, Newland SA, Zhao TX, Lu Y, Sage AS, Sun Y, Sriranjan RS, Ma MKL, Lam BYH, Nus M, Harrison JE, Bond SJ, Cheng X, Silvestre JS, Rudd JHF, Cheriyan J, Mallat Z.  Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction JACC 2021 Sep 14;78(11):1127-114
• Vass L, Fisk M, Cheriyan J, Mohan D, Forman J, Oseni A, Devaraj A, Mäki-Petäjä KM, McEniery CM, Fuld J, Hopkinson NS, Lomas DA, Cockcroft JR, Tal-Singer R, Polkey MI, Wilkinson IB. Quantitative 18 F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD  ERJ Open Res 2021 Aug
• Forsyth F, Brimicombe J, Cheriyan J, Edwards D, Hobbs R, Jalaludeen N, Mant J, Pilling M, Schiff R, Taylor C, Zaman MJ, Deaton C. Characteristics of patients with heart failure with preserved ejection fraction in primary care: Cross-sectional analysis BJGP Open 2021 Aug 31
• Fisk M, Althage M, Moosmang S, Greasley PJ, Cope AP, Jayne DR, Galloway J, Hall F, Wilkinson IB, Ambery P, Cheriyan J.  Endothelin antagonism and sodium glucose Co-transporter 2 inhibition. A potential combination therapeutic strategy for COVID-19 Pulm Pharmacol Ther 2021 Aug;69:102035.
• Cacciottolo PJ, Kostapanos MS, Hernan Sancho E, Pavey H, Kaloyirou F, Vamvaka E, Helmy J, Hubsch A, McEniery CM, Wilkinson IB, Cheriyan J. Investigating the Lowest Threshold of Vascular Benefits from LDL Cholesterol Lowering with a PCSK9 mAb Inhibitor (Alirocumab) in Patients with Stable Cardiovascular Disease (INTENSITY-HIGH): protocol and study rationale for a randomised, open label, parallel group, mechanistic study. BMJ Open 2021 Apr 13;11(4):e037457
• Mäki-Petäjä KM, McGeoch A, Yang LL, Hubsch A, McEniery CM, Meyer PAR, Mir F, Gajendragadkar P, Ramenatte N, Anandappa G, Santos Franco S, Bond SJ, Schönlieb CB, Boink Y, Brune C, Wilkinson IB, Jodrell DI, Cheriyan J. Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension: The HYPAZ Trial Hypertension 2021 May 5;77(5):1591-1599
• Gudu T, Stober C, Cope AP, Cheriyan J, Galloway J, Wilkinson IB, Kostapanos M, Jayne D, Hall F. Baricitinib set to join the COVID-19 therapeutic arsenal?  Rheumatology (Oxford). 2021 Jan 27

2020

• Khan S, Albayaty M, Bush J, Cheriyan J, Cromie A, Koch A, Hammond M, Mair S, Lorch U, Stringer S, Taubel J, Hardman TC. The Association for Human Pharmacology in the Pharmaceutical Industry London Meeting October 2019: Impending Change, Innovation, and Future Challenges. Front Pharmacol. 2020 Nov 19
• Fermont JM, Fisk M, Bolton CE, MacNee W, Cockcroft JR, Fuld J, Cheriyan J, Mohan D, Mäki-Petäjä KM, Al-Hadithi AB, Tal-Singer R, Müllerova H, Polkey MI, Wood AM, McEniery CM, Wilkinson IB; ERICA consortium. Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study. BMJ Open. 2020 Dec 2
• Chen DL, Ballout S, Chen L, Cheriyan J, Choudhury G, Denis-Bacelar AM, Emond E, Erlandsson K, Fisk M, Fraioli F, Groves AM, Gunn RN, Hatazawa J, Holman BF, Hutton BF, Iida H, Lee S, MacNee W, Matsunaga K, Mohan D, Parr D, Rashidnasab A, Rizzo G, Subramanian D, Tal-Singer R, Thielemans K, Tregay N, van Beek EJR, Vass L, Vidal Melo MF, Wellen JW, Wilkinson I, Wilson FJ, Winkler T. Consensus Recommendations on the Use of 18 F-FDG PET/CT in Lung Disease. J Nucl Med. 2020 Dec
• Fermont JM, Mohan D, Fisk M, Bolton CE, Macnee W, Cockcroft JR, McEniery C, Fuld J, Cheriyan J, Tal-Singer R, Müllerova H, Wood AM, Wilkinson IB, Polkey MI; ERICA consortium. Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease. Age Ageing. 2020 Sep 7
• Lu IN, Kulkarni S, Fisk M, Kostapanos M, Banham-Hall E, Kadyan S, Bond S, Norton S, Cope A, Galloway J, Hall F, Jayne D, Wilkinson IB, Cheriyan J. muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized controlled trial. Trials. 2020 Jul 31
• Vass L, Fisk M, Lee S, Wilson FJ, Cheriyan J, Wilkinson I. Advances in PET to assess pulmonary inflammation: A systematic review. Eur J Radiol. 2020 Sep
• Kulkarni S, Fisk M, Kostapanos M, Banham-Hall E, Bond S, Hernan-Sancho E, Norton S, Cheriyan J, Cope A, Galloway J, Hall F, Jayne D, Wilkinson IB. Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients – mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 – Repurposed Drugs (TACTIC-R): A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Jul 8
• McEniery CM, Fisk M, Miles K, Kaloyirou F, Hubsch A, Smith J, Wilkinson IB, Cheriyan J. ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured summary of a study protocol for a randomised controlled trial. Trials. 2020 Jul 14
• Jalaludeen N, Bull SJ, Taylor KA, Wiles JD, Coleman DA, Howland L, Mukhtar O, Cheriyan J, Wilkinson IB, Sharma R, O’Driscoll JM. Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study. Eur J Appl Physiol. 2020 Aug
• Fermont JM, Bolton CE, Fisk M, Mohan D, Macnee W, Cockcroft JR, McEniery C, Fuld J, Cheriyan J, Tal-Singer R, Wilkinson IB, Wood AM, Polkey MI, Müllerova H. Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.​  PLoS One. 2020 Feb 10

2019

• Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr 1]apelin-13 in humans. Sci Rep. 2019 Dec 27
• Vass LD, Lee S, Wilson FJ, Fisk M, Cheriyan J, Wilkinson I. Reproducibility of compartmental modelling of 18 F-FDG PET/CT to evaluate lung inflammation. EJNMMI Phys. 2019 Dec 16
• Kostapanos MS, Cacciottolo PJ, Hubsch A, Pavey H, Hurlock J, Maki-Petaja K, Wilkinson IB, Cheriyan J. Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers – a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale.  J Drug Assess. 2019 Oct 9
• Sun ZDY, Cheriyan J. Non-invasive measurements of arterial function: What? When? Why should we use them? Heart. 2019 Mar 2. pii: heartjnl-2018-312970. doi: 10.1136/heartjnl-2018-312970. [Epub ahead of print] No abstract available.
• Goyal N, Skrdla P, Schroyer R, Kumar S, Fernando D, Oughton A, Norton N, Sprecher DL, Cheriyan J. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342. doi: 10.1007/s40256-018-00320-6.

2018

• Clarke SJ, Giblett JP, Yang LL, Hubsch A, Zhao T, Aetesam-Ur-Rahman M, West NEJ, O’Sullivan M, Figg N, Bennett M, Wewer Albrechtsen NJ, Deacon CF, Cheriyan J, Hoole SP. GLP-1 Is a Coronary Artery Vasodilator in Humans. J Am Heart Assoc. 2018 Nov 20;7(22):e010321. doi: 10.1161/JAHA.118.010321.
• Reijntjes S, Albayaty M, Bush J, Cheriyan J, Cromie A, Koch A, Hammond M, Mair S, Scholes P, Lorch U, Stringer S, Taubel J, Hardman TC. The Association for Human Pharmacology in the Pharmaceutical Industry London Meeting 2018: Brexit and Other Challenges in Early Phase Drug Development. Front Pharmacol. 2018 Nov 19;9:1301. doi: 10.3389/fphar.2018.01301. eCollection 2018. Review.
• Zhao TX, Kostapanos M, Griffiths C, Arbon EL, Hubsch A, Kaloyirou F, Helmy J, Hoole SP, Rudd JHF, Wood G, Burling K, Bond S, Cheriyan J, Mallat Z. Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial. BMJ Open. 2018 Sep 17;8(9):e022452. doi: 10.1136/bmjopen-2018-022452.
• Ellis J, van Maurik A, Fortunato L, Gisbert S, Chen K, Schwartz A, McHugh S, Want A, Santos Franco S, Oliveira JJ, Price J, Coles A, Brown K, Su D, Craigen JL, Yang J, Brett S, Davis B, Cheriyan J, Kousin-Ezewu O, Gray F, Thompson PW, Fernando D. Anti-IL-7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol. 2019 Feb;85(2):304-315. doi: 10.1111/bcp.13748. Epub 2018 Dec 3.
• Mukhtar O, Cheriyan J, Cockcroft JR, Collier D, Coulson JM, Dasgupta I, Faconti L, Glover M, Heagerty AM, Khong TK, Lip GYH, Mander AP, Marchong MN, Martin U, McDonnell BJ, McEniery CM, Padmanabhan S, Saxena M, Sever PJ, Shiel JI, Wych J, Chowienczyk PJ, Wilkinson IB. A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. Am Heart J. 2018 May 20;204:102-108. doi: 10.1016/j.ahj.2018.05.006. Epub 2018 May 20
• Fisk M, Cheriyan J, Mohan D, McEniery CM, Forman J, Cockcroft JR, Rudd JHF, Tal-Singer R, Hopkinson NS, Polkey MI, Wilkinson IB. Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease. Respir Res. 2018 May 24;19(1):100. doi: 10.1186/s12931-018-0792-1.
• Mohan D, Forman JR, Allinder M, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Marchong M, Gale NS, Fisk M, Nagarajan S, Cheriyan J, Lomas DA, Calverley PMA, Miller BE, Tal-Singer R, Wilkinson IB, Polkey MI; ERICA Consortium. Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study. Thorax. 2018 Apr 4. pii: thoraxjnl-2018-211556. doi: 10.1136/thoraxjnl-2018-211556. Epub 2018 Apr 4
• Fisk M*, Cheriyan J*(*joint first authors), Mohan D, Forman J, Mäki-Petäjä KM, McEniery CM, Fuld J, Rudd JHF, Hopkinson NS, Lomas DA, Cockcroft JR, Tal-Singer R, Polkey MI, Wilkinson IB. The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial. PLoS One. 2018 Mar 22;13(3):e0194197. doi: 10.1371/journal.pone.0194197. eCollection 2018.
• Fisk M, McEniery CM, Gale N, Mäki-Petäjä K, Forman JR, Munnery M, Woodcock-Smith J, Cheriyan J, Mohan D, Fuld J, Tal-Singer R, Polkey MI, Cockcroft JR, Wilkinson IB; ERICA Consortium and ACCT Investigators. Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study. Hypertension. 2018 Mar;71(3):499-506. doi: 10.1161/HYPERTENSIONAHA.117.10151. Epub 2018 Jan 22.

2017

• Coello C, Fisk M, Mohan D, Wilson FJ, Brown AP, Polkey MI, Wilkinson I, Tal-Singer R, Murphy PS, Cheriyan J, Gunn RN. Quantitative analysis of dynamic ¹⁸F-FDG PET/CT for measurement of lung inflammation. EJNMMI Res. 2017 Dec;7(1):47. doi: 10.1186/s13550-017-0291-2. Epub 2017 May 25.
• Yang P, Kuc RE, Brame AL, Dyson A, Singer M, Glen RC, Cheriyan J, Wilkinson IB, Davenport AP, Maquire JJ. [Pyr1]Apelin-13(1-12) Is a Biologically Active ACE2 Metabolite of the Endogenous Cardiovascular Peptide [Pyr1]Apelin-13. Front Neurosci 2017 Feb 28;11:92. doi: 10.3389/fnins.2017.00092. eCollection 2017.
• Chen DL, Cheriyan J, Chilvers ER, Choudhury G, Coello C, Connell M, Fisk M, Groves AM, Gunn RN, Holman BF, Hutton BF, Lee S, MacNee W, Mohan D, Parr D, Subramanian D, Tal-Singer R, Thielemans K, van Beek EJ, Vass L, Wellen JW, Wilkinson I, Wilson FJ. Quantification of Lung PET Images: Challenges and Opportunities. J Nucl Med 2017 Feb;58(2):201-207. doi: 10.2967/jnumed.116.184796. Epub 2017 Jan 12.

2016

• Yang L*, Cheriyan J* (*joint first authors), Gutterman DD, Mayer RJ, Ament Z, Griffin JL, Lazaar AL, Newby DE, Tal-Singer R, Wilkinson IB. Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers. Chest2017 Mar;151(3):555-563. doi: 10.1016/j.chest.2016.10.058. Epub 2016 Nov 21.
• Mäki-Petäjä KM, Barrett SM, Evans SV, Cheriyan J, McEniery CM, Wilkinson IB.  Hypertension. 2016 Nov;68(5):1290-1297. Epub 2016 Sep 26.  The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.
• Mäki-Petäjä KM, Day L, Cheriyan J, Hall FC, Östör AJ, Shenker N, Wilkinson IB.  J Am Heart Assoc. 2016 Feb 19;5(2). pii: e002762. doi: 10.1161/JAHA.115.002762.  Tetrahydrobiopterin supplementation improves endothelial function but does not alter aortic stiffness in patients with rheumatoid arthritis.
• Lazaar AL, Yang L, Boardley RL, Goyal NS, Robertson J, Baldwin SJ, Newby DE, Wilkinson IB, Tal-Singer R, Mayer RJ, Cheriyan J^, Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor. Br J Clin Pharmacol 2016 May;81(5):971-9

2015

• Brame AL, Maguire JJ, Yang P, Dyson A, Torella R, Cheriyan J, Singer M, Glen RC, Wilkinson IB, Davenport AP. Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 2015 April 4
• Yang L, Mäki-Petäjä K, Cheriyan J, McEniery C, Wilkinson IB. The role of epoxyeicosatrienoic acids in the cardiovascular system.Br J Clin Pharmacol 2015 Jul;80(1):28-44

2014

• Serg M, Graggabar J, Kampus P, Zagura M, Kals J, Mäki-Petäjä KM, Cheriyan J, Zilmer M, Eha J,  McEniery CM, Wilkinson IB. Value of haemodynamic profiling to the response of antihypertensive therapy. Artery Research Journal 2014 August 26
• Fisk M, Gajendragadkar PR, Mäki-Petäjä KM, Wilkinson IB, Cheriyan J. Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease. Am J Cardiovasc Drugs. 2014 Jun 14
• Gajendragadkar PR, Hubsch A, Mäki-Petäjä KM, Serg M, Wilkinson IB, Cheriyan J. Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial. PloS One 2014 Jun 9.

2013

• Pucci G, Cheriyan J, Hubsch A, Hickson SS, Gajendragadkar PR, Watson T, O’Sullivan M, Woodcock-Smith J, Schillaci G, Wilkinson IB, McEniery CM.
  Evaluation of the Vicorder, a novel cuff-based device for the noninvasive estimation of central blood pressure. J Hypertens 2013 Jan;31(1):77-85.

2012

• Barbour AM, Sarov-Blat L, Cai G, Fossler MJ, Sprecher DL, Graggaber J, McGeoch AT, Maison J, Cheriyan J.  Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Losmapimod following a Single Intravenous or Oral Dose in Healthy Volunteers. Br J Clin Pharmacol 2012 Dec 7. [Epub ahead of print]
• Mäki-Petäjä KM, Elkhawad M, Cheriyan J, Joshi FR, Ostör AJ, Hall FC, Rudd JH, Wilkinson IB.
  Anti-tumor necrosis factor-α therapy reduces aortic inflammation and stiffness in patients with rheumatoid arthritis.Circulation 2012 Nov 20;126(21):2473-80.
• Elkhawad M, Rudd JH, Sarov-Blat L, Cai G, Wells R, Davies LC, Collier DJ, Marber MS, Choudhury RP, Fayad ZA, Tawakol A, Gleeson FV, Lepore JJ, Davis B, Willette RN, Wilkinson IB, Sprecher DL, Cheriyan J.
  Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imaging 2012 Sep;5(9):911-22.

2011

• Cheriyan J, Webb AJ, Sarov-Blat L, Elkhawad M, Wallace SM, Mäki-Petäjä KM, Collier DJ, Morgan J, Fang Z, Willette RN, Lepore JJ, Cockcroft JR, Sprecher DL, Wilkinson IB.
  Inhibition of p38 Mitogen-Activated Protein Kinase Improves Nitric Oxide-Mediated Vasodilatation and Reduces Inflammation in Hypercholesterolemia. Circulation 2011 Feb 8;123(5):515-23. Epub 2011 Jan 24.

2010

• Wallace SM, Mäki-Petäjä KM, Cheriyan J, Davidson EH, Cherry L, McEniery CM, Sattar N, Wilkinson IB, Kharbanda RK.
  Simvastatin prevents inflammation-induced aortic stiffening and endothelial dysfunction. Br J Clin Pharmacol 2010 Dec;70(6):799-806.
• J Cheriyan, CM McEniery and IB Wilkinson. Oxford Specialist Handbook in Hypertension. Oxford University Press 2010. ISBN 9780199229550.
• Cheriyan J, O’Shaughnessy KM, Brown MJ. Primary Prevention of CVD: treating hypertension. BMJ Clinical Evidence. ISSN 1752-8526. Copyright BMJ Publishing Group Limited 2010.

2009

• Cheriyan J, Burton TJ, Bradley TJ, Wallace SM, Mäki-Petäjä KM, Mackenzie IS, McEniery CM, Brown J, Wilkinson IB.
  The effects of urotensin II and urantide on forearm blood flow and systemic haemodynamics in humans. Br J Clin Pharmacol 2009 Oct;68(4):518-23.
• Hickson SS, Butlin M, Mir FA, Graggaber J, Cheriyan J, Khan F, Grace AA, Yasmin, Cockcroft JR, Wilkinson IB, McEniery CM; Anglo-Cardiff Collaboration Trial Investigators.
  The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveform. J Hypertens 2009 Sep;27(9):1784-8.

2008

• Mäki-Petäjä KM, Cheriyan J, Booth AD, Hall FC, Brown J, Wallace SM, Ashby MJ, McEniery CM, Wilkinson IB.
  Inducible nitric oxide synthase activity is increased in patients with rheumatoid arthritis and contributes to endothelial dysfunction. Int J Cardiol 2008 Oct 13;129(3):399-405. Epub 2008 Jun 20.

2007

• Cheriyan J, Wilkinson IB. Role of increased aortic stiffness in the pathogenesis of heart failure. Curr Heart Fail Rep 2007 Sep;4(3):121-6. Review.

2005

• Mackenzie IS, Maki-Petaja KM, McEniery CM, Bao YP, Wallace SM, Cheriyan J, Monteith S, Brown MJ, Wilkinson IB.
  Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans. Arterioscler Thromb Vasc Biol 2005 Sep;25(9):1891-5. Epub 2005 Jul 28.